Plants all going strong? Weeds coming nicely alongside? Start early and get them out while they are small. Hand weeding, and light hoeing are the best. Dandelions? You’ve got a free salad plant there: eat the young leaves, and just remove the flower stems before they spread. Whatever you do please don’t be tempted to use Roundup.It is now very strongly linked to cancer causation (look it up), and is just too risky to use, and, I believe too irresponsible to let any more of it into the groundwater.
Healthy plants don’t succumb to big pest infestations, anyway, so mulching them with good organic matter, and an organic foliage feed when the leaves are established will be of far more benefit to your garden and your family’s health.